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Coordination chemistry of acrylamide and N-pyrazolylpropanamide : syntheses and structures

Autor :Girma Kibatu Berihie
Herkunft :OvGU Magdeburg, Fakultät für Verfahrens- und Systemtechnik
Datum :06.12.2006
 
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Typ :Dissertation
Format :Text
Kurzfassung :The research into the coordination of acrylamide and N-pyrazolylpropanamide chemistry in this work has resulted in the synthesis and characterization of a number of coordination compounds of acrylamide, N-pyrazolylpropanamide, and cobalt and copper complexes of N-pyrazolylpropanamide. Complexes of acrylamide with chlorides, nitrates, perchlorates and tetrafluoroborates of first row divalent manganese, iron, cobalt, nickel, copper and zinc have been prepared and the single crystal structures of these compounds was determined using X-ray diffraction. The ligand acrylamide is exclusively shown to behave as a normal amide donor, with the oxygen of the carbonyl group coordinated to the metal ions. One particular area of interest which has shown significant progress in bioinorganic studies is metal-catalyzed and/or metal-mediated ethanolysis and hydrolysis of acrylamide by way of their conjugate adducts using Cu(II) or Ni(II) salts which mimic the activity of amidase in biological systems. The catalysis in these studies involves direct alkylation of the substrate acrylamide to another ligand which contains an adjacent nitrogen atom resulting in a hemilabile multidentate ligand which then forms intramolecular, weakly oxygen coordinated, 7- or 6- membered metal chelate with the active metallic cores. As a part of interest in the coordination chemistry of acrylamide and acrylamide-based ligands an acrylamide substituted pyrazole ligand, N-pyrazolylpropanamide, and its complexes [CuL2Cl2] and [Co3L4Cl6] (L = N-pyrazolylpropanamide) with copper(II) and cobalt(II) have been synthesized and fully characterized. The structures of these compounds can provide evinces to the ability of acrylamide or acrylamide metabolites to coordinate with trace elements in biological systems and its ability to impact reactivity of the active center in metalloproteins enzymes. Further insights in to the mechanism of metal catalyzed/mediated hydrolysis catalysis of acrylamide via conjugate adducts of an acrylamide substituted ligand in a mononuclear nitrogen/oxygen-ligated metal centre that are relevant to enzyme activity are also described.
Schlagwörter :Acyrlamide; Coordinaton Chemistry
Rechte :Dieses Dokument ist urheberrechtlich geschützt.
Größe :109 Bl.
 
Erstellt am :20.03.2009 - 10:24:25
Letzte Änderung :22.04.2010 - 08:07:17
MyCoRe ID :HALCoRe_document_00006211
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